What is KLOW?
KLOW combines four of the most studied repair-research peptides in one vial. Here is what each component is, what research has found on it, and why researchers combine them.
At a glance
- Type
- Four-peptide blend, co-lyophilized in one vial
- Components
- GHK-Cu, BPC-157, TB-500 and KPV
- Colour
- Blue, from the copper in GHK-Cu
- Appearance
- Blue lyophilized powder
- Our fill size
- 80mg
Four peptides in one vial
Each of KLOW's four components has its own research history. Together they cover several stages of tissue repair.
| Component | What it is | Main research focus |
|---|---|---|
| GHK-Cu | Copper-binding tripeptide found in human plasma | Collagen synthesis, matrix remodelling, wound models1 |
| BPC-157 | 15-amino-acid peptide from a gastric protein | Tendon and soft-tissue repair2 |
| TB-500 | Synthetic peptide modelled on thymosin beta-4 | Cell migration, new blood vessels, wound healing3 |
| KPV | Lys-Pro-Val, the last three amino acids of alpha-MSH | Inflammatory signalling4 |
GHK-Cu, BPC-157 and TB-500 are covered in depth in our GHK-Cu and BPC-157 / TB-500 overviews. KPV is the component unique to KLOW.
KPV, the anti-inflammatory piece
KPV is a three-amino-acid peptide, lysine-proline-valine, taken from the end of alpha-melanocyte-stimulating hormone (alpha-MSH), a hormone with known anti-inflammatory activity. In a 2008 study, KPV was carried into intestinal lining cells by PepT1, a transporter for small peptides that increases in inflamed gut tissue. Once inside, it reduced activation of NF-κB, a central switch for inflammatory signalling, and given by mouth it reduced the severity of colitis in mice, an effect that depended on PepT1.4
Why combine them
Tissue repair runs through overlapping stages: an inflammatory phase, cells migrating into the injury, new blood vessels forming, and the extracellular matrix being rebuilt. The four components map onto those stages in the research: KPV on inflammatory signalling,4 TB-500 on cell migration,3 BPC-157 on tendon repair,2 and GHK-Cu on collagen and matrix remodelling.1 A blend lets researchers study those pathways together and compare the combined effect with each component alone.
KLOW itself has not been the subject of published studies. The research cited here is on its individual components, almost all of it in cell and animal models.
Why KLOW is blue
The blue colour comes from the copper bound in GHK-Cu. The other three peptides are white, so a KLOW vial is blue both as a powder and once reconstituted. Our GHK-Cu overview explains the chemistry.
Handling KLOW in the lab
Lyophilized KLOW is stable stored frozen at −4 °F and protected from light. Let a vial reach room temperature before opening, reconstitute with bacteriostatic water added slowly down the side of the vial, swirl rather than shake, and keep the solution refrigerated at 36–46 °F.
Before using any lot, check its certificate of analysis. Our current KLOW lot, VD-KLOW80-2610, tested at 99.20% purity by HPLC with identity confirmed by LC-MS at VeriPure Labs. View the certificate ↗ or see every lot on our lab reports page.
Frequently asked questions
What is in KLOW?
Four peptides co-lyophilized in one vial: GHK-Cu, BPC-157, TB-500 and KPV.
Why is KLOW blue?
The copper bound in its GHK-Cu component gives the blend its blue colour. The other three peptides are white.
Has KLOW been studied as a blend?
Not in published studies. The research behind it is on its individual components, mostly in cell and animal models.
Is KLOW for human use?
No. Vivid DNA supplies KLOW strictly for laboratory research. It is not a drug, food or supplement, and is not for human or veterinary use.
References
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences. 2018;19(7):1987. doi:10.3390/ijms19071987 ↗
- Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology. 2011;110(3):774–780. PubMed 21030672 ↗
- Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opinion on Biological Therapy. 2012;12(1):37–51. PubMed 22074294 ↗
- Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166–178. PubMed 18061177 ↗
More research overviews
Research use only. Vivid DNA products are sold strictly for laboratory research. They are not drugs, foods, cosmetics or supplements, are not for human or veterinary use, and are not intended to diagnose, treat, cure or prevent any disease. Clinical results described here refer to investigational or approved medicines studied under medical supervision, not to research-grade material. This article summarises published research and has not been evaluated by the Food and Drug Administration.