AMPK signalling
Activation of the cell's energy sensor and downstream metabolic effects.
Cellular
Cellular · research compound
MOTS-C
Mitochondrial open reading frame of the 12S rRNA-c · mitochondrial-derived peptide (MDP)
A 16-amino-acid peptide encoded in mitochondrial DNA, studied for its role in metabolic regulation and AMPK signalling.
$78 / vial
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5vials15% off
6vials20% off
7+vials30% off
Any 5 vials take 15% off the whole order. Mix compounds and sizes; applied automatically at checkout.
For laboratory research use only. Not for human or veterinary use.
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, one of a small family of mitochondrial-derived peptides. It is notable for being produced from the mitochondrial genome yet acting on cellular metabolism more widely, including movement to the nucleus under metabolic stress in cell studies.
Research on MOTS-c centres on AMP-activated protein kinase (AMPK) signalling, glucose uptake and insulin sensitivity in preclinical models, exercise-related metabolic adaptation, and its decline with age, making it a frequent subject in metabolism and mitochondrial-biology studies.
Read the full research overview: how it works, studies and references →
Research applications
Where MOTS-C appears in laboratory and preclinical research.
Insulin sensitivity
Glucose uptake and insulin signalling in preclinical metabolic models.
Exercise biology
Metabolic adaptation and physical-capacity endpoints in animal studies.
Mitochondrial signalling
How the mitochondrial genome communicates with the nucleus.
Specifications
| Product | MOTS-C |
|---|---|
| Also known as | Mitochondrial open reading frame of the 12S rRNA-c · mitochondrial-derived peptide (MDP) |
| Class | Mitochondrial-derived peptide (16 amino acids) |
| Form | Lyophilized (freeze-dried) powder |
| Fill sizes | 10mg, 40mg |
| Purity | 99%+, verified by HPLC for every lot |
| Storage | Lyophilized: −4 °F, protected from light. Reconstituted: 36–46 °F. |
| Documentation | Certificate of analysis for lot VD-MOTS10-2610: report VPL-261008-2295 ↗. Every published certificate is on our lab reports page. Lot number supplied in writing with every order |
| Intended use | Laboratory research only. Not for human or veterinary use. |
MOTS-C FAQ
What is MOTS-c?
MOTS-c is a mitochondrial-derived peptide of 16 amino acids, studied in laboratory research on metabolic regulation, AMPK signalling and insulin sensitivity.
Which vial sizes are available?
MOTS-c comes in 10mg and 40mg lyophilized vials, each HPLC-verified.
Is MOTS-C for human use?
No. MOTS-C is sold strictly for laboratory research use. It is not a drug, food or supplement, and is not for human or veterinary use or for diagnosing, treating or preventing any condition.
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Research use only. All Vivid DNA products are sold strictly for laboratory research. They are not drugs, foods, cosmetics or supplements, are not for human or veterinary use, and are not intended to diagnose, treat, cure or prevent any disease. Statements on this page describe published and preclinical research and have not been evaluated by the Food and Drug Administration.